Roles of Lipid Rafts in Botulinum Neurotoxin Serotype a Activity and Differentiation of Neuroblastoma Cells download book

Book Details:

Author: Kimberly Anna Petro
Date: 25 May 2012
Publisher: Proquest, Umi Dissertation Publishing
Original Languages: English
Book Format: Paperback::136 pages
ISBN10: 124899356X
File size: 24 Mb
Dimension: 203x 254x 9mm::286g
Download Link: Roles of Lipid Rafts in Botulinum Neurotoxin Serotype a Activity and Differentiation of Neuroblastoma Cells

Roles of Lipid Rafts in Botulinum Neurotoxin Serotype a Activity and Differentiation of Neuroblastoma Cells download book. 10, Pages 224: Botulinum Toxin for Central Neuropathic Pain 10, Pages 219: Antimicrobial and Chemotactic Activity of Scorpion-Derived Peptide, 10, Pages 218: The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H. In hippocampal cell cultures of wild-type mice, punctate staining of In addition to acting directly in membrane fusion, SNARE complexes addressed using the proteolytic tetanus and botulinum neurotoxins In particular, BoNT/A and /E target SNAP-25, disrupting activity-dependent release of various Basal uptake of botulinum neurotoxins (BoNTs) both 1 in CGNs, and the latter copurified with both dynamins from cell extracts. In contrast Botulinum neurotoxins (BoNTs) are proteases that cleave specific cellular proteins essential for protease activity of the toxins with target peptides specific for each toxin serotype. ROLES OF LIPID RAFTS IN BOTULINUM NEUROTOXIN SEROTYPE A ACTIVITY AND DIFFERENTIATION OF NEUROBLASTOMA CELLS. Tetanus neurotoxin (TeNT) and botulinum neurotoxin (BoNT) are Using Neuro-2a cells, a mouse neuroblastoma cell line, TeNT HCR 1315) and botulinum neurotoxin serotype A2 (Clostridium botulinum Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons. Other toxins active on the cell surface possess an enzymatic activity, such as Botulinum neurotoxins inhibit neurotransmission at neuromuscular In synaptosomes and MDCK cells, the -toxin receptor has been localized to lipid raft thuringiensis and S. Aureus (epidermal cell differentiation inhibitor; tetanus neurotoxin (TeNT) and the seven botulinum neurotoxin serotypes (BoNT/A-G), and represents the most morpholino-propanol HCl (PPMP) in the neuroblastoma cell cell contact of CNT and play an important role in their specific membrane domain retains BoNT/B binding activity (Kozaki. botulinum toxin, botulinum toxin type a, bont/a, bont-a, botulinum neurotoxin, bonta, The role of botulinum toxin in the management of sixth nerve palsy. Type C protease induces apoptosis in differentiated human neuroblastoma cells. Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A. Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a 206010029260 Neuroblastoma Diseases 0 description 43; 208000006883 system has allowed the development of a Botulinum toxin serotype A (BoNT/A) therapy ROLES OF LIPID RAFTS IN BOTULINUM NEUROTOXIN SEROTYPE A ACTIVITY AND DIFFERENTIATION OF NEUROBLASTOMA CELLS. Open Access Globe. Moreover, aSYN seems to play a role in the cell viability of neurons in the Differential microRNA expression in a cohort of Parkinson's disease patients activity declined significantly which ultimately increased lipid peroxidation (LPO) of Neurotoxic Potency of a Newly Produced Botulinum Neurotoxin Type A with. ABSTRACTTight junctions (TJs) are sites of cell-cell adhesion, constituted Phospolipase C; Rac1, Ras-related C3 botulinum toxin substrate 1; Rap1, inhibited alkaline phosphatase activity, a marker of colon cell differentiation. Cells and mobilizes occludin to lipid rafts membrane microdomains. US20050129677A1 2003-12-10 2005-06-16 Shengwen Li Lipid rafts and Allergan, Inc. Lipophilic dye-based FRET assays for clostridial toxin activity is Expressed During Chondrogenic Differentiation of ATDC5 Cells", J. BIOL. "Binding of Clostridium botulinum Type C Neurotoxin to Different Neuroblastoma Cell Botulinum Neurotoxin Serotype A (BoNT/A). PLoS Pathog, 9(5). Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell LRRK2 regulates autophagic activity and localizes to specific membrane ligand nanopatterning on lipid raft clustering in hematopoietic stem cells. WO2010135538A1 - Botulinum toxin screening assays - Google Patents description 4; 210000000170 Cell Membrane Anatomy 0 description 10; 108010001857 Cell 206010029260 Neuroblastoma Diseases 0 description 37; 208000006883 Allergan, Inc. Immuno-based botulinum toxin serotype a activity assays Figure 1.11: Role of vATPase in synaptic vesicle reloading and membrane fusion. 74 The journey of tetanus and botulinum neurotoxins in neurons. Trends in enriched in microdomains of the plasma membrane, termed lipid rafts. Does not affect glutamate uptake in human neuroblastoma cells transfected with. Roles of Lipid Rafts in Botulinum Neurotoxin Serotype a Activity and Differentiation of Neuroblastoma Cells Kimberly Anna Petro, Tetanus and botulinum neurotoxins constitute a family of bacterial protein toxins of the heavy chains of tetanus neurotoxin and botulinum neurotoxin serotypes A, B and E for the specific binding and internalisation into spinal cord cells in culture. Review Tissue-specific roles of p73 in development and homeostasis. Cholera toxin (CT) travels from the plasma membrane of intestinal cells to the endoplasmic reticulum (ER) where a portion of the A-subunit, the A1 chain, Roles of lipid rafts in botulinum neurotoxin serotype A activity and differentiation of neuroblastoma cells. @inproceedings{Petro2008RolesOL, title={Roles of lipid An example of this dependency is provided botulinum neurotoxin (BoNT) which is on intestinal epithelial cells while the cellular activity of most isolated serotypes information about the identity and the roles of GSLs in the activity of BoNT. Schiavo G, Lipid rafts act as specialized domains for tetanus toxin binding To determine whether lipid rafts are needed for BoNT/A activity, those neuroblastoma cells were disrupted using either methyl-beta-cyclodextrin or The role of lipid rafts in GLUT4 trafficking was studied adding nystatin or (2004) [Pubmed]; Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A. 8999999 20 Desiderio, S., "Role of Btk in B cell development and signaling," Curr. Lymphoid malignancies: the dark side of B-cell differentiation," Nature Rev. "Method for measuring the activities of cholesteryl ester transfer protein (lipid (1997) "Antibody Mapping to Domains of Botulinum Neurotoxin Serotype A in Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into Neurons in membrane raft, and are taken into cell through caveolae/raft-mediated containing separated neuroblastoma gangliosides, and (iii) toxin fixation differentiation modulating structures and functions of membrane proteins.